Migraines are a recurring form of headaches, frequently accompanied by nausea and sensitivity to sound and light. Migraines are extremely common, affecting over 38 million people in the United States. The most common treatments for migraines include pharmaceutical drugs such as triptans, beta-blockers, Opioids, ergots, and antidepressants.

As you probably know, these commonly prescribed medications can lead to dependency and often cause moderate to severe side effects. It’s important to know that pharmaceutical drugs are not your sole option for coping with migraines. Besides modifying your lifestyle choices, you can incorporate CBD into your treatment regimen for plant-sourced, natural migraine headache relief.

What Is A Migraine?

A migraine is a kind of headache that leads to intense throbbing sensation in one region of the head. It might be accompanied by vomiting, nausea, and sensitivity to light or sound.

Generally, migraine headaches are extremely painful. A migraine attack will usually last from 4 to 72 hours. Migraines can, however, stay for several days.

The frequency of attacks differs from person to person. Some people have migraines several times a month, while others much less frequently.

Causes Of Migraines

The precise cause of migraines remains unknown. Research indicates that genetic and environmental factors might play a role.

Studies have associated alterations in the brain and the trigeminal nerve, which mediates pain, to migraines.

Chemical imbalances within the brain might also be involved. Depression and anxiety have long been linked with migraines.

Researchers have discovered that serotonin levels fall during migraine attacks, leading the trigeminal nerve to discharge substances called neuropeptides, which result in headache pain.

Alterations in the weather or barometric pressure, which may cause imbalances in brain chemicals, may trigger a migraine.

Symptoms Of Migraines

The most common symptoms of migraines include:

  • Severe, frequently “pounding,” pain, generally on one side of the head
  • Sensitivity to light
  • Nausea or vomiting
  • Eye pain
  • Sensitivity to sound

How CBD Is Effective For Migraines

CBD can prove effective for relief in migraines due to its potent analgesic, antiemetic, and anti-inflammatory properties.

CBD, Anandamide, and Migraines

Absence of endocannabinoids within the system may largely be responsible for migraine and other conditions also. This condition, which is defined as clinical endocannabinoid deficiency, may lead to migraine headaches in some people.

Anandamide, or AEA, is among several endocannabinoids synthesised in the human body. It has the capacity to both raise and lower the activity of specific serotonin receptors, indicating it has therapeutic uses in the sphere of migraine headaches. AEA is also stated to be tonically active in the periaqueductal gray matter, a migraine generator.

Further research confirms that a dysfunction in the endocannabinoid system may lead to the development of migraine attacks. The authors of the research also advise that modulation of endocannabinoid system receptors, like that which occurs with AEA administration, can be helpful in the therapy of migraine pain.

The potential power of CBD in the treatment of migraine rests on how it can manipulate AEA levels in the body, the endogenous cannabinoid that has been discovered to soothe migraine attacks. CBD has been displayed to inhibit the uptake of AEA and the enzymes that degrade this molecule. This implies that CBD permits anandamide to stay outside of the cells for longer duration of time, where it may display its aforementioned effects.

Assists With Migraine Pain

Our body can produce cannabinoids itself. Cannabinoids have been displayed to act on the body’s individual receptors and inhibit or activate certain processes. The best known receptors are the cannabinoid receptors CB1 and CB2. CB1 is present in the nervous system of our intestines, and within the central nervous system while the CB2 receptor is located on the cells of our immune system. These cannabinoid receptors form part of the endocannabinoid system, which is utilized to regulate body processes that are closely connected with the perception of pain. Just like synthetically produced painkillers, CBD suppresses the formation of inflammatory tissue hormones. It can accordingly be assumed that applying CBD oil and the resulting discharge of certain substances from the nervous system can help heal inflammation and alleviate the pain connected with migraine. Moreover, CBD also addresses the messenger substances that involve the contraction or expansion of blood vessels.

Since CBD oil can impact the serotonin system, it is held that CBD oil is effective in relieving the severe pain of migraine. CBD oil can also help treat migraines by combating the nausea connected with pain due to its antiemetic properties.


CBD, due to its anticonvulsant, antiemetic, analgesic, and anti-inflammatory effects, offers a promising class of compounds for both acute (severe, short-term) as well as prophylactic (preventative) therapy of migraine pain. Besides, it is safe and possesses little adverse side effects rendering it an excellent alternative to more powerful migraine medications.